Full Name: Jian Liu

Position：Professor

E-mail: jianliu@lzu.edu.cn

Address:

School of Pharmacy, Lanzhou University, Lanzhou, Gansu, 730000, China

Education

Sep.2004–Jul.2009

Ph.D., Synthetic organic Chemistry, State Key Laboratory of Applied organic Chemistry,Lanzhou University, P.R. CHINA

Sep.2000–Jul.2004  

B.S.,Chemistry, Department of Chemistry and Chemical Engineering, Lanzhou University, P.R. CHINA

Professional Background

Oct.2017-Present

Professor, School of Pharmacy, Lanzhou University

Aug.2014-Oct.2017

Associate Professor, Department of Chemistry and Chemical Engineering, Xiamen University,

Dec.2009–Jul.2014

Research Associate of Medicinal Chemistry in Prof. Floyd Romesberg’s Lab of The Scripps Research Institute. USA

Teaching: Organic Chemistry

Research Interests

Carbohydrates serve as the fundamental energy source for life processes on Earth, playing pivotal roles in a myriad of biological processes, including energy metabolism, signal transduction, immunological recognition, and membrane formation. Despite their significant physiological functions, the number of carbohydrate-based drugs utilized in clinical settings remains limited. The primary challenges in carbohydrate chemistry stem from the chemical inconvenience caused by the high density of OH groups and the difficulty of stereoselective glycosidic bond construction. We aim to devise innovative strategies for the selective modification of carbohydrates and the de novo synthesis of carbohydrate derivatives from non-sugar substrates. We are actively exploring potential therapeutic applications of these novel compounds.

Google Scholar page: https://scholar.google.com.hk/citations?user=bkntzhIAAAAJ&hl=en

Honor and Awards

2016, won the First Prize of Scientific and Technological Progress awarded by Gansu Province.

Representative Publications

1.Synthesis of a New Coumarin Dye for pH Independent Staining of Lysosomes. Tetrahedron Lett 59, 4376–4379 (2018). 

2.Organelle-Directed Staudinger Reaction Enabling Fluorescence-on Resolution of Mitochondrial Electropotentials via a Self-Immolative Charge Reversal Probe. Anal Chem 90, 2954–2962 (2018). 

3.Dithiane-Induced [3+2] Cycloaddition Tactic for the Convergent Synthesis of Dihydropyrrole and Pyrrole Derivatives. J Org Chem 85, 14847–14857 (2020). 

4.Stereodivergent synthesis of C-glycosamino acids via Pd/Cu dual catalysis. Sci China Chem 64, 552–557 (2021). 

5.4CzIPN Catalyzed Photochemical Oxidation of Benzylic Alcohols. Tetrahedron Lett 67, 152878 (2021). 

6.Site-selective C–H alkylation of myo -inositol via organic photoredox catalysis. Chem Commun 58, 9934–9937 (2022). 

7.Nonenzymatic Asparagine Motif Synthesis by Photoredox-Catalyzed Carbamoylation of Dehydroalanine. J Org Chem 87, 6852–6859 (2022). 

8.Enzyme-like C–H Oxidation of Glucosides Promoted by Visible Light. CCS Chem 4, 3599–3608 (2022). 

9.Late-stage functionalization of glucosides and aminoglycosides to combat bacterial resistance. ChemRxiv (2022) doi:10.26434/chemrxiv-2022-s2p4k.