Full Name: Chen Shi-Wu

Position：Ph.D, Professor

E-mail: chenshw@lzu.edu.cn

Address:

School of Pharmacy，Lanzhou University, Lanzhou 730000, China

Education

Sept.2001‒Jun.2006 Ph.D. degree at Lanzhou University, Major in organic Chemistry

Sept.1990‒Jun.1994 B.S. degree at North-West Normal University, Major in Chemistry

Professional Background

May 2012‒ Professor of Medicinal Chemistry, School of Pharmacy, Lanzhou University

Apr.2007‒Apr.2012 Associate Professor of Medicinal Chemistry, School of Pharmacy, Lanzhou University

Nov.2006‒Aug.2008 Visiting scholar in HongKong University, HongKong

Nov.2004‒Mar.2007 Lecturer of Analytical Chemistry, School of Pharmacy, Lanzhou University

Dec.2000‒Nov.2004 Lecturer of Analytical Chemistry, School of Pharmacy, Lanzhou Medical College

Jul.1994‒Nov.2000 Assistant of Analytical Chemistry, Department of Pharmacy, Lanzhou Medical College

Teaching

Research and development of drugs (for graduate students)

Analytical Chemistry (for undergraduate students)

Organic Reactions for Drug Synthesis (for undergraduate students)

Research Interests

Research experience

Responsible for research projects: “The General Program of National Natural Science Foundation of China (21372110, 21672093)”, “The General Program of National Natural Science Foundation of Gansu Province (1208RJZA247)”.

Research Interests

1.Design, synthesis and biological evaluation of kinases inhibitors

2.Studies on antitumor agents based on active natural products

3.Optimization of preparation process of non patent drugs

Honor and Awards

2015, won the second Prize of the State Scientific and Technological Progress.

2013, won the second Prize of the Pharmaceutical Development Award of Gansu Pharmaceutical Association.

Representative Publications

1.Wei Wang, Xiu Feng, Huan-Xiang Liu, Shi-Wu Chen*, Ling Hui. Synthesis and biological evaluation of 2,4-disubstituted phthalazinones as Aurora kinase inhibitors Bioorg. Med. Chem. 2018, impress (https://doi.org/10.1016/j.bmc.2018.04.048).

2.Chun-Yan Sang, Heng-Zhi Tian, Yue Chen, Jian-Fei Liu, Shi-Wu Chen*, Ling Hui*.  Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4′-O-demethyl- 4-deoxypodophyllotoxins as topoisomerase-II inhibitors. Bioorg. Med. Chem. Lett. 2018, 28(2), 71–76.

3.Xiao-Hui Xu, Xiao-Wen Guan, Shi-Liang Feng, You-Zhen Ma, Shi-Wu Chen*, Ling Hui*. One-pot synthesis and biological evaluation of N-(aminosulfonyl)- 4-podophyllotoxin carbamates as potential anticancer agents. Bioorg. Med. Chem. Lett. 2017, 27(13), 2890–2894.

4.Rong Xiang*, Xiao-Wen Guan, Ling Hui, Yong-Xin Jin, Shi-Wu Chen*. Investigation of the anti-angiogenesis effects induced by deoxypodophyllotoxin–5-FU conjugate C069 against HUVE cells. Bioorg. Med. Chem. Lett. 2017, 27(4), 713–717.

5.Zhen-Bo Tang, Yao-Zhang Chen, Jie Zhao, Xiao-Wen Guan, Yong-Xin Bo, Shi-Wu Chen*, Ling Hui*. Conjugates of podophyllotoxin and norcantharidin as dual inhibitors of topoisomeraseⅡ and protein phosphatase 2A. Eur. J. Med. Chem. 2016, 123, 568–576.

6.Xiao-Wen Guan, Xiao-Hui Xu, Shi-Liang Feng, Zhen-Bo Tang, Shi-Wu Chen*, Ling Hui*. Synthesis of hybrid 4-deoxypodophyllotoxin–5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest. Bioorg. Med. Chem. Lett. 2016, 26(6), 1561–1566.

7.Ling Hui*, Chun-Yan Sang, Dong-Hong Wang, Xiao-Hui Wang, Mei-Liang Wang, Qing-Hua Jia, Ming-Ren Ma, Shi-Wu Chen*. Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non‑small cell lung cancer cells in vitro. Molecular Medicine Reports, 2016. 13: 339–346.

8.Wen-Wen Qin, Chun-Yan Sang, Lin-Lin Zhang, Wei Wei, Heng-Zhi Tian, Huan-Xiang Liu, Shi-Wu Chen*, Ling Hui*. Synthesis and biological evaluation of 2,4-diaminepyrimides as selective Aurora A kinase inhibitors. Eur. J. Med. Chem. 2015, 95, 174–184.

9.Jie Zhao, Xiao-Wen Guan, Shi-Wu Chen*, Ling Hui. Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25(2), 363–366.

10.Chun-Yan Sang, Xiao-Hui Xu, Wen-Wen Qin, Jian-Fei Liu, Ling Hui, Shi-Wu Chen*. DPMA, a deoxypodophyllotoxin derivative, induces apoptosis and anti-angiogenesis in non-small cell lung cancer A549 cells. Bioorg. Med. Chem. Lett. 2013, 23(24), 6650−6655.

11.Chun-Yan Sang, Jian-Fei Liu, Wen-Wen Qin, Jie Zhao, Ling Hui, Yong-Xin Jin, Shi-Wu Chen*. Synthesis and evaluation of the apoptosis inducing and CT DNA interaction properties of a series of 4β-carbamoyl 4'-O-demethylepi- podophyllotoxins. Eur. J. Med. Chem. 2013, 70, 59−67.

12.Jian-Fei Liu, Chun-Yan Sang, Wen-Wen Qin, Jie Zhao, Ling Hui, Yi-Lan Ding, Shi-Wu Chen*. Synthesis and evaluation of the cell cycle arrest and CT DNA interaction properties of 4β-amino-4-O-demethyl-4-deoxypodophyllotoxins. Bioorg. Med. Chem. 2013, 23(21), 6948−6955.

13.Xuan Liu, Lin-Lin Zhang, Xiao-Hui Xu, Ling Hui, Jin-Bang Zhang, Shi-Wu Chen*. Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin. Bioorg. Med. Chem. Lett. 2013, 23(13), 3780−3784.

14.Jian-Fei Liu, Chun-Yan Sang, Xiao-Hui Xu, Lin-Lin Zhang, Ling Hui, Jin-Bang Zhang, Shi-Wu Chen*. Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin. Eur. J. Med. Chem. 2013, 64, 621−628.